Tadalafil/Cialis (CIA) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 (PDE-5) inhibitor with a fairly long acting effect. PDE-5 inhibitors are being researched in its strong abilities to enhance erection and even treat subjects with erectile dysfunction (ED) in various species. CIA is a great compound to research in this field because PDE-5 inhibitors are selective blockers of PDE-5, which leads to hydrolysis of cyclic guanosine monophosphate (cGMP) to its monophosphates.

cGMP is a potent vasodilator and nitric oxide donor and this function plays a big role in blood flow to many parts of the body including genitals and has shown to be very effective at vasodilation and arterial constriction that leads to more blood to flow to the genitals and less to leave. This results in firmer and longer lasting erections that have been shown many times in research subjects.

The promise of this compound doesn’t stop there. It has also been shown to have anti-inflammatory and cardio-protective effects as well that are currently being researched. Pharmacokinetic research also shows the administration of low-dose Tadalafil is a very safe option for longterm research and has also already been shown to be very effective in the treatment for ED in research subjects.

REF:
1) Anti-Inflammatory and Cardioprotective Effects of Tadalafil in Diabetic Mice.Varma A, Das A, Hoke NN, Durrant DE, Salloum FN, Kukreja RC. http://www.ncbi.nlm.nih.gov/pubmed/23028874