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Letrozole is a non-steroidal selective aromatase-inhibitor, and it is widely known as the strongest and most effective research A-I. Letrozole prevents the enzyme aromatase from attaching to testosterone, thus preventing the production of estrogen. This compound effectively passes thru the cell membrane of lipid fat cells and helps break down estrogen deposits. The benefits are clear for the subject as it effectively reduces estrogenic side effects in research subjects.